Instruct patients to read the “Instructions for Use” carefully for complete directions on how to properly dose and administer Clion Taper by decreasing the total daily dose by 5 to 10 mg/day on a weekly basis until discontinued. Recommended Total Daily Dosing by Weight GroupĪs with all antiepileptic drugs and benzodiazepines, withdraw Clion Do not proceed with dose escalation more rapidly than weekly, because serum concentrations of Clion and its active metabolite require 5 and 9 days, respectively, to reach steady-state. Each dose in Table 1 (e.g., 5 to 20 mg in ≤30 kg weight group) has been shown to be effective, although effectiveness increases with increasing dose. Individualize dosing within each body weight group, based on clinical efficacy and tolerability. ![]() Oral Suspension greater than 5 mg should be administered in divided doses twice daily a 5 mg daily dose can be administered as a single dose. An oral suspension is expected to be available in 2013. The oral preparation was FDA approved on October 21, 2011. It has been marketed as an anxiolytic since 1975 and an anticonvulsant since 1984. Lennox-Gastaut syndrome: Adjunctive treatment of seizures associated with Lennox-Gastaut syndrome in patients ≥2 yearsĭata from a limited number of patients studied suggest that Clion may be beneficial for the treatment of catamenial epilepsy.īased on the American Academy of Neurology and the American Epilepsy Society practice guideline update summary on the efficacy and tolerability of the new antiepileptic drugs II: treatment-resistant epilepsy, Clion is possibly effective as add-on therapy for treatment-resistant adult focal epilepsy.Ĭlion belongs to the 1,5-benzodiazepine class of drugs and is expected to have a better side-effect profile compared to older 1,4-benzodiazepines. Do not take 2 doses at once.Īsk your health care provider any questions you may have about how to use Clion suspension. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
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